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Aldosterone and the mineralocorticoid receptor in insulin resistance and diabetes

 doi: 10.24875/ALAD.M17000001

Freddy J.K. Toloza, Carlos O. Mendivil

Aldosterone is a key regulator of water and electrolyte metabolism, but recent evidence from multiple lines of research also identifies it as a major player in other chronic disorders, particularly diabetes and the metabolic syndrome. In this review, we summarize rel- evant aspects of aldosterone production, secretion, action, the way aldosterone and the mineralocorticoid receptor may impact energy metabolism, and useful take-home messages concerning mineralocorticoid antagonism in patients with type 2 diabetes mellitus.

Palabras clave: Aldosterone. Electrolyte metabolism. Diabetes. Metabolic syndrome.

Revista ALAD

ISSN: 2248-6518 | Esta revista es propiedad de la Asociación Latinoamericana de Diabetes